Non disponible en dehors du Royaume-Uni et de l'Irlande
Biochem/physiol Actions
The gene LXR α (liver X receptor α) encodes a protein that plays an important role in the control of cholesterol homeostasis. LXRs have been found to regulate inflammatory response in macrophages. They are also involved in the regulation of cell proliferation.
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Features and Benefits
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General description
The gene LXR α (liver X receptor α) is a member of LXRs that belong to the nuclear receptor superfamily. The encoded protein is expressed predominantly in macrophages, liver, intestine, kidney, lung and adipose tissue. The gene is mapped to human chromosome 11p11.2. The protein contains a DNA-binding domain that requires the ligand-binding domain to heterodimerize with a retinoid X receptor partner for its DNA-binding activity.
Immunogen
LXR-A antibody was raised against a 15 amino acid peptide from near the amino terminus human LXR-A.
Linkage
The action of this antibody can be blocked using blocking peptide SBP3500178.
Physical form
Supplied in PBS with 0.02% sodium azide.
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