Anticorps Anti - JMJD1A produit en lapin, anticorps isolé affinité, solution aqueuse tamponnée

Non disponible en dehors du Royaume-Uni et de l'Irlande

Biochem/physiol Actions

Jumonji domain containing 1A protein (JMJD1A) is a histone demethylase and specifically demethylates mono- and dimethyl-H3K9. It has also been found to be a novel interaction partner with ER71, a transcription factor expressed in the testes of adult mice and during embryogenesis. JMJD1A is also a downstream gene of signal transducer and activator of transcription 3 (STAT3), a protein that has been found to be important in the maintenance of mouse embryonic stem (mES) cells. Decreased JMJD1A expression is correlated with the differentiation of cultured mES cells following the removal of the cytokine leukemia inhibitory factor (LIF). These findings suggest that JMJD1A might be a signaling molecule having a role in maintaining pluripotency in embryonic stem cells.

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Features and Benefits

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General description

The jumonji domain containing 1A protein (JMJD1A) was originally discovered as a testes specific gene, but has been found to be expressed in numerous tissues. At least two isoforms of JMJD1A are known to exist. This antibody will not cross-react with JMJD1B or JMJD1C.

Immunogen

JMJD1A antibody was raised against a 16 amino acid peptide from near the amino terminus of human JMJD1A.

Linkage

The action of this antibody can be blocked using blocking peptide SBP3500093.

Physical form

Supplied at approx. 1 mg/mL in phosphate buffered saline containing 0.02% sodium azide.