Anti-alpha-Tubulin du poulet, anticorps isolé affinité, solution aqueuse tamponnée

Non disponible en dehors du Royaume-Uni et de l'Irlande

Application

Anti-α-tubulin from chicken has been used for Western blotting and immunohistochemistry.

Biochem/physiol Actions

Gene mutation of tubulin α-1A (TUBA1A) is observed in perisylvian asymmetrical polymicrogyria, polymicrogyria-like cortical dysplasia, and microlissencephaly in fetal cases. Alteration in the expression of the gene impairs neural migration and causes lissencephaly (LIS).

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Features and Benefits

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General description

Tubulin α 1A (TUBA1A) is a member of α-tubulin gene family. It is encoded by the gene mapped to human chromosome 12q13.12. Tubulin α 1A is a vital structural subunit of microtubules that are temporarily expressed in almost all post-mitotic neurons during neuronal development. The encoded protein structure contains a core of two β-sheets enclosed by α-helices. TUBA1A is characterized with an amino-terminal domain having guanine nucleotide-binding region, an intermediate domain and a carboxy-terminal domain.

Immunogen

Tubulin antibody was raised against a 16 amino acid peptide near the amino terminus of human Tubulin.

Linkage

The action of this antibody can be blocked using blocking peptide SBP3500023.

Physical form

Supplied at approx. 1 mg/mL in phosphate buffered saline containing 0.02% sodium azide.