Anticorps Anti - FNIP2 produit en lapin, anticorps isolé affinité, solution aqueuse tamponnée, ab2

Non disponible en dehors du Royaume-Uni et de l'Irlande

Biochem/physiol Actions

Folliculin interacting protein 2 (FNIP2) induces apoptosis. It associates with AMP-activated protein kinase (AMPK) and folliculin (FLCN). The protein also has a role in the O⁶-methylguanine-induced apoptosis signaling pathway.

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Features and Benefits

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General description

Folliculin interacting protein 2 (FNIP2) is a 125.6kDa protein expressed in the cytoplasm.

Immunogen

FNIP2 antibody was raised against an 18 amino acid peptide near the amino terminus of human FNIP2.

Linkage

The action of this antibody can be blocked using blocking peptide SBP3500010.

Physical form

Supplied at approx. 1 mg/mL in phosphate buffered saline containing 0.02% sodium azide.

Target description

FNIP2 is the second protein found to interact with folliculin, the product of the Birt-Hogg-Dube (BHD) gene. Folliculin is thought to act as a tumor suppressor as mutations or loss of heterozygosity in this gene are associated with BHD syndrome-related renal tumors. Folliculin and FNIP1, a protein that shares 49% identity to FNIP2, bind to AMPK, an important energy sensor in cells that negatively regulates the mammalian target of rapamycin (mTOR), a protein that is thought to be the master switch for cell growth and proliferation. FNIP1 and FNIP2 are able to form homo- and heteromeric multimers, suggesting these proteins may have a functional relationship. Multiple isoforms of FNIP2 are known to exist. This antibody is predicted to not cross-react with FNIP1.