Anticorps Anti - MYOD1 produit en lapin, immunoglobulin purifié, solution aqueuse tamponnée

Non disponible en dehors du Royaume-Uni et de l'Irlande

Biochem/physiol Actions

Myogenic differentiation 1 (MYOD1) associates with histone-modifying enzymes and stimulates muscle differentiation by elevating the expression of histone H3 mono methyl K4 (H3K4me1) and histone H3 acetyl 27 (H3K27ac). MyoD1 staining can be considered as a key adjunct in the sorting of pediatric soft-tissue sarcomas. Mutation in the gene is associated with the pathogenesis of perinatally lethal fetal akinesia.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Myogenic differentiation 1 (MYOD1) is encoded by the gene mapped to human chromosome 11p15.1. The encoded protein belongs to the basic helix-loop-helix (bHLH) family of transcription factors. MYOD1 is expressed exclusively during normal skeletal muscle myogenesis and in rhabdomyosarcomas.

Immunogen

MYOD1 (NP_002469.2, 1 a.a. ~ 320 a.a) full-length human protein.SequenceMELLSPPLRDVDLTAPDGSLCSFATTDDFYDDPCFDSPDLRFFEDLDPRLMHVGALLKPEEHSHFPAAVHPAPGAREDEHVRAPSGHHQAGRCLLWACKACKRKTTNADRRKAATMRERRRLSKVNEAFETLKRCTSSNPNQRLPKVEILRNAIRYIEGLQALLRDQDAAPPGAAAAFYAPGPLPPGRGGEHYSGDSDASSPRSNCSDGMMDYSGPPSGARRRNCYEGAYYNEAPSEPRPGKSAAVSSLDCLSSIVERISTESPAAPALLLADVPSESPPRRQEAAAPSEGESSGDPTQSPDAAPQCPAGANPNPIYQVL

Physical form

Solution in phosphate buffered saline, pH 7.4