Anti-EPB41L3 anticorps produit dans la souris, immunoglobulin purifiée, solution aqueuse tamponnée

Non disponible en dehors du Royaume-Uni et de l'Irlande

Biochem/physiol Actions

Erythrocyte membrane protein band 4.1-like 3 (EPB41L3)/protein 4.1B helps in linking cellular receptors with the cytoskeleton. It possesses tumor-suppressive action. In human, overexpression of EPB41L3 gene can stimulate apoptosis in breast cancer, non-small cell lung cancer, and meningioma cells.

General description

Erythrocyte membrane protein band 4.1-like 3 (EPB41L3)/protein 4.1B is expressed at high levels in the brain and neurons. Adipose tissue, kidney, testis, adrenal gland, and placenta also show high expression of EPB41L3. It is moderately expressed in the lungs and intestines. EPB41L3 gene is located on human chromosome 18p11.31. Protein 4.1B belongs to the protein 4.1 superfamily of proteins. It has an N-terminal 4.1/ezrin/radixin/moesin (FERM) domain.

Immunogen

EPB41L3 (AAH06141.1, 1 a.a. ~ 865 a.a) full-length human protein.SequenceMTTESGSDSESKPDQEAEPQEAAGAQGRAGAPVPEPPKEEQQQALEQFAAAAAHSTPVRREVTDKEQEFAARAAKQLEYQQLEDDKLSQKSSSSKLSRSPLKIVKKPKSMQCKVILLDGSEYTCDVEKRSRGQVLFDKVCEHLNLLEKDYFGLTYRDAENQKNWLDPAKEIKKQVRSGAWHFSFNVKFYPPDPAQLSEDITRYYLCLQLRDDIVSGRLPCSFVTLALLGSYTVQSELGDYDPDECGSDYISEFRFAPNHTKELEDKVIELHKSHRGMTPAEAEMHFLENAKKLSMYGVDLHHAKDSEGVEIMLGVCASGLLIYRDRLRINRFAWPKVLKISYKRNNFYIKIRPGEFEQFESTIGFKLPNHRAAKRLWKVCVEHHTFFRLLLPEAPPKKFLTLGSKFRYSGRTQAQTRRASALIDRPAPYFERSSSKRYTMSRSLDGASVNENHEIYMKDSMSAAEVGTGQYATTKGISQTNLITTVTPEKKAEEERDEEEDKRRKGEEVTPISAIRHEGKTDSERTDTAADGETTATEELEKTQDDLMKHQTNISELKRTFLETSTDTAVTNEWEKRLSTSPVRLAARQEDAPMIEPLVPEEKMETKTESSGIETEPTVHHLPLSTEKVVQETVLVEERRVVHASGDASYSAGDSGDAAAQPAFTGIKGKEGSALTEGAKEEGGEEVAKAVLEQEETAAASRERQEEQSAAIHISETLEQKPHFESSTVKTETISFGSVSPGGVKLEISTKEVPVVHTETKTITYESSQVDPGTDLEPGVLMSAQTITSETTSTTTTTHITKTVKGGISETRIEKRIVITGDADIDHDQALAQAIKEAKEQHPDMSVTKVVVHKETEITPEDGED

Physical form

Solution in phosphate buffered saline, pH 7.4