Monoclonal Anti-TNS4 antibody produced in mouse, clone 1C1, purified immunoglobulin, buffered aqueous solution

Not available outside of the UK & Ireland.

Application

Monoclonal Anti-TNS4 antibody produced in mouse is suitable for indirect ELISA and western blot.

Biochem/physiol Actions

TNS4 (Tensin 4) is mainly involved in cell migration activity. 1 It exhibits oncogenic property in colonic, breast, lung, and gastric cancers. In studies, its overexpression has been reported in the pancreatic cancer cells. In pancreatic cancer cells, TNS4 promotes colony formation and cell motility. It has been predicted that TNS4 could be a prognostic marker for primary melanoma.

General description

TNS4 (Tensin 4) is a signaling molecule localized in the prostate and placenta. It is a member of the TENSIN gene family. It has a Src homology 2 and phosphotyrosine-binding domains. Its expression has been observed in the early progression of melanoma cells.

Mouse monoclonal antibody raised against a full-length recombinant TNS4.

Immunogen

TNS4 (AAH18706, 1 a.a. ~ 480 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.SequenceMGSKASSPHGLGSPLVASPRLEKRLGGLAPQRGSRISVLSASPVSDVSYMFGSSQSLLHSSNSSHQSSSRSLESPANSSSSLHSLGSVSLCTRPSDFQAPRNPTLTMGQPRTPHSPPLAKEHASSCPPSITNSMVDIPIVLINGCPEPGSSPPQRTPGHQNSVQPGAASPSNPCPATRSNSQTLSDAPFTTCPEGPARDMQPTMKFVMDTSKYWFKPNITREQAIELLRKEEPGAFVIRDSSSYRGSFGLALKVQEVPASAQSRPGEDSNDLIRHFLIESSAKGVHLKGADEEPYFGSLSAFVCQHSIMALALPCKLTIPQRELGGADGASDSTDSPASCQKKSAGCHTLYLSSVSVETLTGALAVQKAISTTFERDILPTPTVVHFKVTEQGITLTDVQRKVFFRRHYPLTTLRFCGMDPEQRKWQKYCKPSWIFGFVAKSQTEPQENVCHLFAEYDMVQPASQVIGLVTALLQDAERM

Physical form

Solution in phosphate buffered saline, pH 7.4