Anticorps Monoclonal Anti - MYLIP produit dans la souris, clone 3C10, immunoglobulin purifiée, solution aqueuse tamponnée

Non disponible en dehors du Royaume-Uni et de l'Irlande

Biochem/physiol Actions

Myosin regulatory light chain interacting protein (MYLIP) might have a role in cholesterol uptake. It modulates the levels of low density lipoprotein receptor by controlling the ubiquitination of the intracellular tail of the receptor and its lysosomal degradation. Overexpression of the protein in mice livers has been shown to cause hypercholesterolemia and atherosclerosis.

Disclaimer

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General description

Myosin regulatory light chain interacting protein (MYLIP) is an E3 ubiquitin ligase. The gene encoding it is localized on human chromosome 6p22.3.

Mouse monoclonal antibody raised against a full-length recombinant MYLIP.

Immunogen

MYLIP (AAH02860, 1 a.a. ~ 445 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.SequenceMLCYVTRPDAVLMEVEVEAKANGEDCLNQVCRRLGIIEVDYFGLQFTGSKGESLWLNLRNRISQQMDGLAPYRLKLRVKFFVEPHLILQEQTRHIFFLHIKEALLAGHLLCSPEQAVELSALLAQTKFGDYNQNTAKYNYEELCAKELSSATLNSIVAKHKELEGTSQASAEYQVLQIVSAMENYGIEWHSVRDSEGQKLLIGVGPEGISICKDDFSPINRIAYPVVQMATQSGKNVYLTVTKESGNSIVLLFKMISTRAASGLYRAITETHAFYRCDTVTSAVMMQYSRDLKGHLASLFLNENINLGKKYVFDIKRTSKEVYDHARRALYNAGVVDLVSRNNQSPSHSPLKSSESSMNCSSCEGLSCQQTRVLQEKLRKLKEAMLCMVCCEEEINSTFCPCGHTVCCESCAAQLQSCPVCRSRVEHVQHVYLPTHTSLLNLTVI

Physical form

Solution in phosphate buffered saline, pH 7.4