Monoclonal Anti-PHC2 antibody produced in mouse, clone 1F4, purified immunoglobulin, buffered aqueous solution

Not available outside of the UK & Ireland.

General description

In Drosophila melanogaster, the ′Polycomb′ group (PcG) of genes are part of a cellular memory system that is responsible for the stable inheritance of gene activity. PcG proteins form a large multimeric, chromatin-associated protein complex. The protein encoded by this gene has homology to the Drosophila PcG protein ′polyhomeotic′ (Ph) and is known to heterodimerize with EDR1 and colocalize with BMI1 in interphase nuclei of human cells. The specific function in human cells has not yet been determined. Two transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq)

Immunogen

PHC2 (NP_004418.2, 91 a.a. ~ 200 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.SequencePYLQESKEEGAPLKLKCELCGRVDFAYKFKRSKRFCSMACAKRYNVGCTKRVGLFHSDRSKLQKAGAATHNRRRASKASLPPLTKDTKKQPTGTVPLSVTAALQLTHSQE

Physical form

Solution in phosphate buffered saline, pH 7.4