ANTI-APCDD1 (N-TERMINAL)

Non disponible en dehors du Royaume-Uni et de l'Irlande

Biochem/physiol Actions

Adenomatosis polyposis coli down-regulated 1 (APCDD1) inhibits wnt (wingless/integrated) signalling and promotes human hair growth. Mutations in APCDD1 results in a rare autosomal dominant hereditary hypotrichosis, which is characterized by hair loss due to hair follicle miniaturization. APCDD1 is directly regulated by β-catenin/T-cell factor 4 (TCF4). The high expression of Apcdd1 in colon cancer cells promotes its proliferation. APCDD1 is essential for adipocyte differentiation. Downregulation of APCDD1 in diet induced obesity impairs adipocyte differentiation and causes obesity related metabolic diseases.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Adenomatosis polyposis coli down-regulated 1 (APCDD1) encodes a membrane bound glycoprotein. Apcdd1 is predominantly expressed in epidermal and dermal compartments of human hair follicles. In human chromosome, the gene APCDD1 is localized on 18p11.22.

Physical form

Supplied in PBS with 0.09% (W/V) sodium azide