ANTI-LECT1 (N-TERM)

Not available outside of the UK & Ireland.

General description

LECT1 is a glycosylated transmembrane protein that is cleaved to form a mature, secreted protein. The N-terminus of the precursor protein shares characteristics with other surfactant proteins and is sometimes called chondrosurfactant protein although no biological activity has yet been defined for it. The C-terminus of the precursor protein contains a 25 kDa mature protein called leukocyte cell-derived chemotaxin-1 or chondromodulin-1. The mature protein promotes chondrocyte growth and inhibits angiogenesis. This protein expressed in the avascular zone of prehypertrophic cartilage and its expression decreases during chondrocyte hypertrophy and vascular invasion. The mature protein likely plays a role in endochondral bone development by permitting cartilaginous anlagen to be vascularized and replaced by bone. It may be involved also in the broad control of tissue vascularization during development.

Immunogen

LECT1 (NP_008946, 3-35)This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human LECT1.

Physical form

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.