Anticorps antidrosophila Parkin (C-term) produit dans un lapin de lapin, sulfate d'ammonium saturé (SAS) précipité, solution aqueuse tamponnée

Non disponible en dehors du Royaume-Uni et de l'Irlande

Application

Anti-Drosophila Parkin (C-term) antibody produced in rabbit has been used in western blotting.

Biochem/physiol Actions

Mutation in the parkin gene leads to Parkinson′s disease. The encoded protein is involved in quality control mechanism for the disposal of abnormal mitochondria, thereby maintaining lifespan and controlling locomotion. Parkin along with PTEN-induced putative kinase 1 (PINK1) targets mitochondria for its degradation through autophagy.

Disclaimer

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General description

Parkin is thought to play a role in the ubiquitin/proteasome pathway for protein degradation. The amino terminus bears sequence homology to ubiquitin while functionally it acts as a RING-type ubiquitin protein ligase (E3) that coordinates the transfer of ubiquitin to substrate proteins, thus targeting them for degradation by the proteasome. Mutations in the human version of the protein are known to cause autosomal recessive juvenile parkinsonism.

Parkin gene is located on Drosophila melanogaster chromosome 78C2. This gene codes for the enzyme E3 ubiquitin ligase, which localizes in the cytosol.

Immunogen

PARKIN (NP_730600, )This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of Drosophila Parkin.

Physical form

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.