Anti-RNF4 (176-190) antibody produced in rabbit, IgG fraction of antiserum, buffered aqueous solution

Not available outside of the UK & Ireland.

Application

Anti-RNF4 (176-190) antibody produced in rabbit has been used in western blotting analysis.

Biochem/physiol Actions

Really interesting new gene (RING ) finger protein 4 (RNF4) catalyzes the ubiquitylation of proteins associated with small ubiquitin-related modifier (SUMO). Rnf4 is involved in DNA repair, in transcription and chromatin regulation. It is also associated with the process of hematopoiesis. RNF4 is implicated in acute promyelocytic leukemia, acute myeloid leukemia, Fanconi anemia and aplastic anemia.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Really interesting new gene (RING ) finger protein 4 (RNF4) gene encodes ubiquitin E3 ligase, an enzyme widely expressed in many tissues. The protein contains a RING (really interesting new gene) finger domain and around three small ubiquitin-related modifier (SUMO)-interaction motifs. RNF4 is mapped to human chromosome 4p16.3.

Immunogen

synthetic peptide corresponding to amino acids 176-190 of human RNF4

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Target description

RNF4 (176-190), ring finger protein 4. encodes a protein that contains a RING finger motif and acts as a transcription regulator. This protein has been shown to interact with, and inhibit the activity of, TRPS1, a transcription suppressor of GATA-mediated