Anticorps Anti - S1P1 produit dans le lapin, anticorps isolé affinité, solution aqueuse tamponnée

Non disponible en dehors du Royaume-Uni et de l'Irlande

Biochem/physiol Actions

S1P1 (sphingosine-1-phosphate receptor 1) acts as an anti-apoptotic/pro-proliferative protein in AML (acute myeloid leukemia) cells. It participates in angiogenesis and lymphangiogenesis. It is considered as a pro-tumorigenic receptor, as it induces migration of cancer cell and invasion along with tumor neovascularization.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

S1P1 (sphingosine-1-phosphate receptor 1) is one of the transmembrane G protein coupled receptor. It is a member of the endothelial differentiation gene (EDG) family of receptors, hence it is also known as endothelial differentiation gene (EDG-1). It is located on chromosome 1p21.

Immunogen

a 14 amino acid peptide near the carboxy-terminus of the human S1P1.

Linkage

The action of this antibody can be blocked using blocking peptide SBP4809.

Physical form

Solution in phosphate buffered saline containing 0.02% sodium azide