Récepteur de facteur de croissance Anti - nerf / anticorps TNFRSF16 produit en goat, anticorps isolé affinité, poudre lyophile

Non disponible en dehors du Royaume-Uni et de l'Irlande

Application

Anti-Nerve Growth Factor Receptor/TNFRSF16 antibody may be used for immunoblotting at a working concentration of 2 µg/ml. For immunohistochemistry a working concentration of 5-15 µg/ml is recommended.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Neurotrophins (NT) are growth factors that are essential for the development and maintenance of the nervous system. One of the receptors that mediate the effects of NTs is the Nerve Growth Factor Receptor/TNFRSF16 (p75NGFR, p75NTR). Nerve growth factor (NGF) binds to either to NGF receptor (NGFR) or the Trk receptor and can elicit biological responses through each of the receptors independently. NGFR mediates the effects of NGF that are important in the survival and differentiation of neurons and neural crest-derived cells during embryonic and early postnatal development and maintenance of peripheral neurons. Signaling of NGF through NGFR is also implicated in inflammation and allergic reactions. Expression of NGFR has been associated with favourable prognosis and survival in breast and pancreatic cancers Anti-Nerve Growth Factor Receptor/TNFRSF16 recognizes mouse NGF R.

Immunogen

purified, NSO cell-derived recombinant mouse nerve growth factor receptor extracellular domain.

Physical form

Lyophilized from a 0.2 µm filtered solution in phosphate buffered saline containing carbohydrates.

Target description

Anti-Nerve Growth Factor Receptor/TNFRSF16 recognizes mouse NGF R. Neurotrophic factors control the survival, differentiation and maintenance of neurons in the peripheral and central nervous systems, and of other neural crest-derived cell types.