Anticorps Monoclonal Anti - MAGE - C1 PRODUIT dans la souris, environ 1 mg/ mL, clone CT7 - 33, immunoglobulin purifié, solution aqueuse tamponnée

Non disponible en dehors du Royaume-Uni et de l'Irlande

Application

Anti-MAGE-C1 antibody, Mouse monoclonal has been used in: enzyme-linked immunosorbent assay (ELISA) immunocytochemistry immunoblotting immunoprecipitation immunohistochemistry

Biochem/physiol Actions

MAGE family member C1 (MAGE-C1) has been studied as the most expressed cancer or testis antigen in multiple myeloma.

Although the physiological role of melanoma-associated antigen (MAGE) proteins is unknown, it has been reported that MAGE-C1 interacts and co-localizes with an additional cancer testis antigen, NY-ESO-1, in melanoma cells.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

MAGE family member C1 (MAGE-C1) belongs to the melanoma antigen gene (MAGE) family and consists of 1142 amino acids. The gene encoding MAGE-C1 is localized on human chromosome Xq26-27 and has four exons.

Anti-MAGE-C1 antibody, Mouse monoclonal (mouse IgG1 isotype) is derived from the hybridoma CT7-33 produced by the fusion of mouse myeloma cells (SP2/0 cells) and splenocytes from mice immunized with human recombinant MAGE-C1. The first melanoma-associated antigen (MAGE) to be identified was MAGE-A1. The MAGE family of proteins contains over 25 genes that have now been identified in human. These proteins share a homologous region, named the MAGE homology domain (MHD).

Immunogen

human recombinant MAGE-C1.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Target description

MAGE-C1 is a member of the melanoma antigen gene (MAGE) family. The proteins of this family are tumor-specific antigens that can be recognized by autologous cytolytic T lymphocytes.