Nicotinic receptor monoclonal antibody, a1 subunit (mab 35)

Not available outside of the UK & Ireland.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Immunogen

nicotinic acetylcholine receptor from the electric eel Electrophorus.

Legal Information

Sold with permission of the Salk Institute

Physical form

Solution in 20 mM Na₃PO₄, pH 7.2, containing 150 mM NaCl and 0.05 % sodium azide.

Specificity

Binds to the main immunogenic region on the extracellular surface of the α₁ subunit of muscle AChR′s and to homologous regions on α₃ and α₅ subunits of neuronal AChR′s. The epitope is located on the extracellular surface of the α₁ subunit of the muscle nicotinic acetylcholine receptor. The antibody binds to denatured chick α₅ AChR, but does not bind well to denatured α₃, α₄, α₇, α_8, and β₂. It may also bind β₃ due to homology of main immunogenic region. May be used to localize and detect the α₁, α₃ and α₅ subunits of the nicotinic acetylcholine receptor (AChR).