Anti-potassium channel k v1.7

Not available outside of the UK & Ireland.

Immunogen

peptideTTRKAQEIHGKAPG (C) corresponding to residues 2-15 of mouse Kv1.7.

Physical form

Lyophilized powder from phosphate buffered saline, pH 7.4, containing 1% BSA and 0.025% sodium azide.

Reconstitution

Reconstitute the lyophilized vial with 50 µL or 200 µL deionized water, depending on package size. Further dilutions should be made using a carrier protein such as BSA (1-3%).

Target description

K_v1.7 voltage-gated K⁺ channel is a member of the Shaker family of K⁺ channels that includes eight members (K_v1.1- K_v1.8). The biophysical and pharmacological properties of the K_v1.7 channel closely resemble that of the ultra-rapidly activating delayed rectifier (I_Kur) in cardiac tissue. This current plays a central role in cardiac atria repolarization that was largely believed to correspond to the activity of the K_v1.5 channel.