Anticorps Anti - Potassium canal Kv11.2 (erg2) produit en lapin, anticorps isolé affinité, poudre lyophile

Non disponible en dehors du Royaume-Uni et de l'Irlande

Biochem/physiol Actions

The gene Kcnh6 (potassium voltage-gated channel subfamily H member 6) encodes a voltage gated K⁺ channel that modulates the membrane potential in its rested and activated state. It may participate in the tweaking of the presynaptic membrane potential, thereby regulating neurotransmitter release.

Disclaimer

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General description

The gene Kcnh6 (potassium voltage-gated channel subfamily H member 6), also referred to as erg2, encodes a subunit of ether-à-go-go related (erg) K⁺ channels. The erg K+ channels are part of the EAG (ether-à-go-go) family of voltage-gated K⁺ channels. The encoded protein is found to be expressed in the rat retina. The three isoforms erg1, erg2, and erg3 are found to be expressed in the brain. They are strongly expressed in the olfactory bulb.

Immunogen

peptide TLNFVEFNLEKHRS(C), corresponding to residues 185- 198 of human Kv11.2 located in N-terminal part of human Kv11.2.

Physical form

Lyophilized from phosphate buffered saline, pH 7.4, containing 1% BSA and 0.025% sodium azide.

Reconstitution

Reconstitute with 50 µL or 200 µL deionized water, depending on package size. Further dilutions should be made using a carrier protein such as BSA (1-3%).

Target description

Potassium Channel K_V11.2 (erg2) encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming (alpha) subunit. K_v11.2 produces currents characterized by strong inward rectification with slow activation and very rapid inactivation kinetics, which closely resemble those produced by the much studied channel K_v11.1. The expression of K_v11.2 seems to be limited to the brain and the pituitary gland.