Anti-ptrh2

Non disponible en dehors du Royaume-Uni et de l'Irlande

Application

Anti-PTRH2 antibody produced in rabbit, a Prestige Antibody, is developed and validated by the Human Protein Atlas (HPA) project . Each antibody is tested by immunohistochemistry against hundreds of normal and disease tissues. These images can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. The antibodies are also tested using immunofluorescence and western blotting. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.

Biochem/physiol Actions

Peptidyl-tRNA hydrolase 2 (PTRH2) takes part in integrin-mediated cell survival and apoptosis signaling. PTRH2 prevents the peptidyl-tRNAs from accumulating once they dissociate from the ribosomes. After the integrin-mediated cell attachment, it interacts with focal adhesion kinase (FAK) and induces cell survival. It has an important role in anoikis, cell death due to loss of cell attachment to the extra cellular matrix. When this occurs, PTRH2 moves from mitochondria into the cytosol. It then forms a complex with the transcriptional regulator amino-terminal enhancer of split (AES) to mediate apoptosis. PTRH2 suppresses the phosphorylation of extracellular signal-regulated kinase (ERK). It regulates nuclear factor κβ (NFκβ) and ERK signaling. Mutations in the gene have been associated with an infantile multisystem neurologic, endocrine and pancreatic disease (IMNEPD).

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Features and Benefits

Prestige Antibodies^® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies^® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.Every Prestige Antibody is tested in the following ways: IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues. Protein array of 364 human recombinant protein fragments.

General description

Peptidyl-tRNA hydrolase 2 (PTRH2) is primarily a mitochondrial protein and is mainly expressed in the developing brain. It contains an amino-terminal signaling sequence which is involved in its mitochondrial localization.

Immunogen

Peptidyl-tRNA hydrolase 2, mitochondrial precursor recombinant protein epitope signature tag (PrEST)

Legal Information

Prestige Antibodies is a registered trademark of Sigma-Aldrich Co. LLC

Linkage

Corresponding Antigen APREST72010.

Physical form

Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide