Anti-pdlim4

Non disponible en dehors du Royaume-Uni et de l'Irlande

Application

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.Immunohistochemistry (1 paper)

Biochem/physiol Actions

PDLIM4 (PDZ and LIM domain 4) is an actin associated protein consisting of a LIM (Lin11/Isl1/Mec3) domain and PDZ (PSD-95/Dlg/ZO-1) domain. It is generally expressed within the cytokine cluster. It is a tumor suppressor gene, which actively suppresses Src activation through interacting with Src and PTPL1 (Protein tyrosine phosphatase 1). As a result, it leads to a series of Src inactivation cycle. Therefore, silencing of the gene directly disrupts the Src inactivation cycle followed by aberrant Src activation in human cancers. It also consists of two putative transcription start points (tsp) responsible for potential binding of transcriptional factors. Mutation in the PDLIM4 is associated with radial bone mineral density (BMD) and osteoporosis.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Features and Benefits

Prestige Antibodies^® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies^® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.Every Prestige Antibody is tested in the following ways: IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues. Protein array of 364 human recombinant protein fragments.

Immunogen

PDZ and LIM domain protein 4 recombinant protein epitope signature tag (PrEST)

Legal Information

Prestige Antibodies is a registered trademark of Sigma-Aldrich Co. LLC

Linkage

Corresponding Antigen APREST71491.

Physical form

Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide