Anti-psmc5

Not available outside of the UK & Ireland.

Application

Anti-PSMC5 antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.

Biochem/physiol Actions

26S protease regulatory subunit 8 is an enzyme encoded by the PSMC5 gene in humans and is important for the transcription of MHC II molecules. It has a role in regulating transcription of class I MHC and the MHC II-like molecules, HLA-DM and HLA-DO. PSMC5 acts as a key regulator of collagen contraction in primary human lung fibroblasts (a functional characteristic of myofibroblasts) and is a critical step in the process of fibrosis.

General description

PSMC5 (proteasome 26S subunit, ATPase, 5) is a regulatory subunit of the 26S proteasome belonging to the family of putative ATPases. It has structural homology with yeast Sug1p gene.

Immunogen

Immunogen Sequence: GI # 24497435, sequence 2-160

Recombinant proteasome 26S ATPase subunit 5

Physical form

Solution in phosphate buffered saline containing 0.02% sodium azide.