Anti-vldl

Non disponible en dehors du Royaume-Uni et de l'Irlande

Application

Anti-VLDL antibody produced in chicken is suitable for indirect ELISA and western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.

Biochem/physiol Actions

The very-low-density-lipoprotein receptor (VLDLR) is a transmembrane lipoprotein receptor and belongs to low-density-lipoprotein (LDL) receptor family. It is encoded by the VLDLR gene in humans. The LDL receptor gene family members are involved in ligand-mediated signal transduction. VLDLR is involved in the Reelin signaling pathway helping in neuronal migration in the cerebral cortex and cerebellum. It is strongly induced during adipogenesis and actively participates in adipocyte hypertrophy. VLDLR contributes to adipose tissue inflammation and mediates VLDL-induced lipid accumulation. It induces inflammation and ER stress in adipocytes and macrophages. VLDL receptor also plays a role in signaling processes.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Physical form

Solution in phosphate buffered saline containing 0.02% sodium azide.