Anti-GABAA Receptor (alpha3 subunit) antibody produced in rabbit, affinity isolated antibody, lyophilized powder

Non disponible en dehors du Royaume-Uni et de l'Irlande

Application

Anti-GABA_A Receptor (α3 subunit) antibody produced in rabbit is suitable for immunohistochemistry at a working dilution of 1:200 using rat brain frozen sections and immunoblotting at 1:200-1:300 using rat brain membranes.

Biochem/physiol Actions

The inhibitory neurotransmitter GABA signals through two distinct types of pre- and postsynaptic receptors, GABA_A and GABA_B. Both GABA receptors can regulate depression of synaptic transmission and be involved in the inhibition controlling neuronal excitability. α3 is a subtype of GABAA receptor expressed selectively by serotonergic and GABAergic neurons. Serotonergic neurons express strong α3 immunoreactivity but, do not show any α1 immunoreactivity. On the contrary, GABAergic neurons express both α1 and α3 subunits.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

GABA_A and GABA_B receptors differ with regard to their ionic characteristics and pharmacological properties. The GABA_A receptor is an ionotropic receptor that forms the GABA gated chloride channel and consists of several heterogeneous subunits with membrane recognition sites for benzodiazapenes.

Immunogen

peptide corresponding to amino acid residues 1-15 of human GABA(A) receptor α3 subunit. Identical in rat and mouse. Highly conserved (14/15 residues) in bovine.

Physical form

Lyophilized from phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin, 5% sucrose and 0.025% sodium azide