Anti-Calcium Channel CaV3.3 (alpha1I) antibody produced in rabbit, affinity isolated antibody, lyophilized powder

Not available outside of the UK & Ireland.

Application

Anti-Calcium Channel CaV3.3 (a1I) antibody produced in rabbit is suitable for western blot at a dilution of 1:200 using rat brain membranes.

Biochem/physiol Actions

Calcium channel CaV3.3 (α1I) is involved in neuronal excitability and is particularly recruited during the depolarizing after-potential. It is responsible for generating sustained electrical activity. Sperm specific proteins CatSper1 and CatSper2 interact with Cav3.3 and suppress Cav3.3-evoked T-type calcium channel activity.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Calcium channel CaV3.3 (α1I) is a low-voltage-activated T-type calcium channel. CaV3.3 (α1I) transcripts are detected in central nervous system as well as thyroid and adrenal glands.

Immunogen

peptide corresponding to amino acid residues 1053-1067 of rat Ca_V3.3. Homology with other species: human is 14/15 residues identical.

Physical form

Lyophilized from phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 0.05% sodium azide.