Sous-unité de récepteur Anti - GABA (a) gamma - 2

Non disponible en dehors du Royaume-Uni et de l'Irlande

Analysis Note

ControlPC12 cell lysate

Application

Research CategoryNeuroscience

Research Sub CategoryNeurotransmitters & Receptors

This Anti-GABA(A) receptor subunit gamma-2 Antibody is validated for use in WB for the detection of GABA(A) receptor subunit gamma-2.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

GABA(A) receptor subunit gamma-2 is a protein belonging to a subclass of GABA receptors known as GABA (A). GABA (A) receptors are pentameric chloride channels composed of subunits belonging to different homology classes, i.e. α, β, γ, δ, θ, ε, π, and act as receptors for GABA, a crucial inhibitory neurotransmitter localized within the brain. GABA (A) gamma 2 subunit consists of 5 cysteine residues and carries the binding site for benzodiazepine. The subunit functions to promote receptor maintenance and clustering at the synapse, interacts with GABA receptor associated proteins such as GODZ and GABAWRAP, affects GABA (A) receptor conductance and kinetics, and is a contributing component to receptors participating in both phasic and tonic inhibition. Several mutations in the GABA(A) receptor subunit gamma-2 expression have been linked to epileptic syndromes that result in fibrile seizures.

Immunogen

GST-tagged recombinant protein corresponding to rat GABA(A) receptor subunit gamma-2.

Physical form

Rabbit polyclonal serum containing 0.05% sodium azide.

Unpurified

Quality

Evaluated by Western Blot in PC12 cell lysate.

Western Blot Analysis: 1:1,000 dilution of this antibody detected GABA(A) receptor subunit gamma-2 on 10 µg of PC12 cell lysate.

Specificity

This antibody recognizes GABA(A) receptor subunit gamma-2.

Storage and Stability

Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.

Target description

~60 kDa observed