Hydrochlorure de doxorubicine, (HPLC), adapté à la fluorescence, 98,0- 102,0% (HPLC)

Name: Hydrochlorure de doxorubicine, (HPLC), adapté à la fluorescence, 98,0- 102,0% (HPLC)
Brand: SIGMA-ALDRICH
SKU: 44583-50MG
Price: 1575.05 USD

Code: 44583-50MG D2-231

Non disponible en dehors du Royaume-Uni et de l'Irlande

Application

Doxorubicin was used to induce apoptosis, and to induce cardiotoxicity in SK-N-MC cells . It is used to inhibit macromolecular biosynthesis.

Biochem...

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Non disponible en dehors du Royaume-Uni et de l'Irlande
Application
Doxorubicin was used to induce apoptosis, and to induce cardiotoxicity in SK-N-MC cells . It is used to inhibit macromolecular biosynthesis.
Biochem/physiol Actions
Doxorubicin ia an antitumor antibiotic that intercalates DNA and inhibits macromolecular biosynthesis. DNA replication is haulted due to the inhibition of topoisomerase II. It is an inhibitor of reverse transcriptase and RNA polymerase and is an immunosuppressive agent .
General description
Chemical structure: tetracycline
Other Notes
Keep container tightly closed in a dry and well-ventilated place.
Packaging
1, 10, 50 mg in glass bottle
Bottomless glass bottle. Contents are inside inserted fused cone.

antibiotic activity spectrum neoplastics
assay 98.0-102.0% (HPLC)
biological source synthetic
color orange to dark red
fluorescence λ_ex 470 nm; λ_em 585 nm in ethanol
form solid
Gene Information human ... TOP2A(7153)
InChI key MWWSFMDVAYGXBV-RUELKSSGSA-N
InChI 1S/C27H29NO11.ClH/c1-10-22(31)13(28)6-17(38-10)39-15-8-27(36,16(30)9-29)7-12-19(15)26(35)21-20(24(12)33)23(32)11-4-3-5-14(37-2)18(11)25(21)34;/h3-5,10,13,15,17,22,29,31,33,35-36H,6-9,28H2,1-2H3;1H/t10-,13-,15-,17-,22+,27-;/m0./s1
mode of action enzyme | inhibits, DNA synthesis | interferes
mp 216 °C (dec.) (lit.)
Quality Level 200
SMILES string Cl[H].COc1cccc2C(=O)c3c(O)c4C[C@](O)(C[C@H](O[C@H]5C[C@H](N)[C@H](O)[C@H](C)O5)c4c(O)c3C(=O)c12)C(=O)CO
solubility H₂O: 50 mg/mL, clear, orange to red, THF: soluble, methanol: soluble, ethanol: soluble, DMSO: soluble
storage temp. 2-8°C
suitability suitable for fluorescence

Fiche de données de sécurité
Safety Data Sheet for 44583-50MG
Certificat d'analyse
Certificat d'analyse Sigma

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Cas Number 25316-40-9

Ce produit répond aux critères suivants pour être admissible aux récompenses suivantes :

Hydrochlorure de doxorubicine, (HPLC), adapté à la fluorescence, 98,0- 102,0% (HPLC)

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antibiotic activity spectrum	neoplastics
assay	98.0-102.0% (HPLC)
biological source	synthetic
color	orange to dark red
fluorescence	λ_ex 470 nm; λ_em 585 nm in ethanol
form	solid
Gene Information	human ... TOP2A(7153)
InChI key	MWWSFMDVAYGXBV-RUELKSSGSA-N
InChI	1S/C27H29NO11.ClH/c1-10-22(31)13(28)6-17(38-10)39-15-8-27(36,16(30)9-29)7-12-19(15)26(35)21-20(24(12)33)23(32)11-4-3-5-14(37-2)18(11)25(21)34;/h3-5,10,13,15,17,22,29,31,33,35-36H,6-9,28H2,1-2H3;1H/t10-,13-,15-,17-,22+,27-;/m0./s1
mode of action	enzyme \| inhibits, DNA synthesis \| interferes
mp	216 °C (dec.) (lit.)
Quality Level	200
SMILES string	Cl[H].COc1cccc2C(=O)c3c(O)c4C[C@](O)(C[C@H](O[C@H]5C[C@H](N)[C@H](O)[C@H](C)O5)c4c(O)c3C(=O)c12)C(=O)CO
solubility	H₂O: 50 mg/mL, clear, orange to red, THF: soluble, methanol: soluble, ethanol: soluble, DMSO: soluble
storage temp.	2-8°C
suitability	suitable for fluorescence