TH5487

Code: SML2531-25MG D2-231

Non disponible en dehors du Royaume-Uni et de l'Irlande

Biochem/physiol Actions

TH5487 is an inhibitor of 8-oxoguanine DNA glycosylase 1 (OGG1), which is part of the DNA base excision repair pathway. TH5487 as shown to inhibit OGG...


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$764.64 25MG
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Non disponible en dehors du Royaume-Uni et de l'Irlande

Biochem/physiol Actions

TH5487 is an inhibitor of 8-oxoguanine DNA glycosylase 1 (OGG1), which is part of the DNA base excision repair pathway. TH5487 as shown to inhibit OGG1-dependent proinflammatory gene expression by binding in the OGG1 active site, preventing OGG1 from engaging damaged DNA in vitro and in cells, resulting in decreased proinflammatory gene expression.

assay≥98% (HPLC)
colorwhite to beige
formpowder
SMILES stringIC1=CC=C(NC(N2CCC(N(C3=CC=CC(Br)=C3N4)C4=O)CC2)=O)C=C1
solubilityDMSO: 2 mg/mL, clear
storage temp.2-8°C
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