SAJM589

Code: SML2198-5MG D2-231

Non disponible en dehors du Royaume-Uni et de l'Irlande

Biochem/physiol Actions

sAJM589 is a Myc inhibitor that disrupts the Myc-Max heterodimer with an IC50 value of 1.8 µM. sAJM589 was shown to suppress cellular proliferati...


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$118.60 5MG
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Non disponible en dehors du Royaume-Uni et de l'Irlande

Biochem/physiol Actions

sAJM589 is a Myc inhibitor that disrupts the Myc-Max heterodimer with an IC50 value of 1.8 µM. sAJM589 was shown to suppress cellular proliferation in a variety of MYC-dependent cancer cell line including strong inhibition of Burkitt lymphoma Raji cell line growth. The mechanism of action of sAJM589 is thought to involve increased ubiquitination of Myc by inhibition of Max binding to Myc, leading to proteasome-mediated degradation.

assay≥98% (HPLC)
coloryellow to orange
formpowder
SMILES stringOC1=C2C(C=CC=C2)=C3C(N=C(C=CC=C4)C4=N3)=C1
solubilityDMSO: 2 mg/mL, clear (warmed)
storage temp.−20°C
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