Sch 28080

Not available outside of the UK & Ireland.

Application

SCH-28080 was used to treat zebrafish embryos to study the role of H⁺/K⁺-ATPase in establishment of left-right axis during development.

Biochem/physiol Actions

SCH-28080 is a potent inhibitor of gastric H+ and K+-ATPase. The novel antiulcer agents, SCH-28080 and SCH-32651 were examined for their ability to inhibit the H+K+ ATPase enzyme activity in a preparation of microsomal membranes from rabbit fundic mucosa. SCH- 28080 inhibited the isolated enzyme activity with a potency similar to omeprazole, IC₅₀s of 2.5 and 4.0 µM respectively. SCH 32651 was less potent exhibiting an IC₅₀ of 200.0 µM. Both compounds may therefore exert their antisecretory activity via a direct inhibition of the parietal cell H+K+ ATPase.

Packaging

10, 50 mg in glass bottle