Non disponible en dehors du Royaume-Uni et de l'Irlande
Application
This heterobifunctional, PEGylated crosslinker features a carboxylic acid at one end and Boc-protected amino group at the other, which can be deprotected with mildly acidic conditions. The hydrophillic PEG linker facilitates solubility in biological applications. BocNH-PEG4-acid can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC® molecules) for targeted protein degradation
Legal Information
PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license
Other Notes
A Hexylchloride-Based Catch-and-Release System for Chemical Proteomic ApplicationsA Biocompatible Condensation Reaction for the Labeling of Terminal Cysteine Residues on Proteins
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