Non disponible en dehors du Royaume-Uni et de l'Irlande
Application
Lyso SM (d18:1) has been used: to study its effect on the skeletal muscle ryanodine receptor (RyR1), in the presence and absence of calmodulin through single channel recordings in planar lipid bilayersas an inhibitor of Ca2+ sensor calmodulin (CaM)as a standard in circular dichroism (CD) spectroscopy to determine lipid selectivity of the lipid-peptide interactions
Biochem/physiol Actions
Lyso SM (d18:1) or sphingosylphosphorylcholine (SPC) is a lipid mediator that exhibits second messenger functions. It regulates ryanodine receptors (RyRs) and releases Ca2+ from the sarco/endoplasmic reticulum. Lyso SM (d18:1) acts as an endogenous inhibitor of ubiquitous Ca2+sensor calmodulin (CaM).
General description
Lyso SM (d18:1), also known as sphingosylphosphorylcholine (SPC), is a bioactive lipid molecule. This lysophospholipid is present in normal blood plasma, ascites and various tissues.
Packaging
5 mL Amber Glass Screw Cap Vial (860600P-50mg)
5 mL Amber Glass Screw Cap Vial (860600P-10mg)
5 mL Amber Glass Screw Cap Vial (860600P-25mg)
5 mL Amber Glass Screw Cap Vial (860600P-5mg)
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