Non disponible en dehors du Royaume-Uni et de l'Irlande
General description
A cell-permeable plant-derived pentacyclic triterpene acid that displays anti-inflammatory, immunomodulatory, and antitumor activities. Shown to inhibit the phosphatase activity of SHP2, PTP1B, and TCPTP (IC50 = 2.73, 3.08 and 3.33 µM, respectively) as well as induce IR autophosphorylation independent of its phosphatase inhibitory activity. Ursolic acid is also reported to inhibit NF-κB and STAT3 pathway activation in cancer cultures, resulting in enhanced sensitivity to chemotherapy agents and apoptotic cell death.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Other Notes
Li, Y., et al. 2010. Int. J. Cancer127, 462.Pathak, A.K., et al. 2007. Mol. Cancer Res.5, 943.Jung, S.H., et al. 2007. Biochem. J.403, 243.Zhang, W., et al. 2006. Biochim. Biophys. Acta1760, 1505.Shishodia, S., et al. 2003. Cancer Res.63, 4375.
Packaging
Packaged under inert gas
50 mg in Glass bottle
Reconstitution
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Warning
Toxicity: Standard Handling (A)
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