Non disponible en dehors du Royaume-Uni et de l'Irlande
Biochem/physiol Actions
Primary TargetPlasma and glandular kallikreins
Cell permeable: no
Reversible: no
Product does not compete with ATP.
General description
Potent and specific irreversible inhibitor of plasma and glandular kallikreins. Inhibits the cleavage of atrial naturiuretic peptide (ANP 1-126) by kallikreins. Also inhibits adrenal kininogenase, a kallikrein-like enzyme.
Potent and specific irreversible inhibitor of plasma and glandular kallikreins. Also available as a 10 mM solution in H2O (Cat. No. 508573).
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Other Notes
Byrne, R.E., and Scanu, A.M. 1989. J. Lipid Res. 30, 109.Scicli, G., et al. 1989. Adv. Exp. Med. Biol.247B, 217.Gibson, T.R., et al. 1987. Endocrinology120, 764.Kettner, G., and Shaw, E. 1981. Methods Enzymol.80, 826.
Packaging
10 mg in Plastic ampoule
Reconstitution
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
Sequence
H-D-Phe-Phe-Arg-chloromethylketone, 2TFA
Warning
Toxicity: Standard Handling (A)
Ce produit répond aux critères suivants pour être admissible aux récompenses suivantes :