Not available outside of the UK & Ireland.
Biochem/physiol Actions
Primary TargetInhibiting ribonucleotide reductase
Cell permeable: no
Reversible: no
Product does not compete with ATP.
General description
Antineoplastic agent. Blocks DNA replication by inhibiting ribonucleotide reductase. Induces apoptosis in chronic myelogenous leukemia lymphocytes.
Anti-neoplastic agent that blocks DNA replication by inhibiting ribonucleotide reductase. Induces apoptosis in chronic myelogenous leukemia lymphocytes. Reported to enhance the radiation effects in pancreatic adenocarcinoma cells. Releases NO in the presence of oxidizing agents.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Other Notes
Leyden, D., et al. 2000. Anticancer Res.20, 133.Tsuchiya, K., et al. 1999. Free Radic. Biol. Med. 27, 347.Anand, S., et al. 1995. Cancer Lett.88, 101.
Packaging
5 g in Plastic ampoule
Reconstitution
Following reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 2 months at 4°C.
Warning
Toxicity: Carcinogenic / Teratogenic (D)
This product has met the following criteria to qualify for the following awards: