XL413 HYDROCHLORURE

Code: SML1401-5MG D2-231

Non disponible en dehors du Royaume-Uni et de l'Irlande

Biochem/physiol Actions

XL413 is a selective inhibitor of the serine-threonine kinase CDC7 (cell division cycle 7 homolog), a regulator of cell cycle checkpoint control that ...


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$273.28 5MG
DEMANDER

Non disponible en dehors du Royaume-Uni et de l'Irlande

Biochem/physiol Actions

XL413 is a selective inhibitor of the serine-threonine kinase CDC7 (cell division cycle 7 homolog), a regulator of cell cycle checkpoint control that has been implicated in protecting tumor cells from apoptotic cell death during replication stress. XL413 has an IC50 of 3.4 nM for CDC7, compared to 215 nM, 42 nM and 18 nM for CK2, PIM1 and pMCM2, respectively. XL413 caused significant tumor growth regression in rodent models, causing cell cycle arrest in the late S to G2 phase.

Packaging

5, 25 mg in glass bottle

assay≥98% (HPLC)
colorwhite to beige
formpowder
InChI keyUYBMDYGAVMHMGF-FVGYRXGTSA-N
InChI1S/C14H12ClN3O2.CH4/c15-7-3-4-10-8(6-7)11-12(20-10)14(19)18-13(17-11)9-2-1-5-16-9;/h3-4,6,9,16H,1-2,5H2,(H,17,18,19);1H4/t9-;/m0./s1
Quality Level100
SMILES stringClC1=CC2=C(C=C1)OC3=C2N=C([C@H]4NCCC4)NC3=O.C
solubilityH2O: 5 mg/mL, clear
storage conditiondesiccated
storage temp.−20°C
Cas Number1169562-71-3
Hazard Class6.1
Un Number2811
Pack GroupIII
Ce produit répond aux critères suivants pour être admissible aux récompenses suivantes :



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