M-110

Non disponible en dehors du Royaume-Uni et de l'Irlande

Biochem/physiol Actions

M-110 is a highly isoform-selective, cell permeable and potent ATP-competitive inhibitor of the PIM kinase family that prefers PIM-3. M-110 is an inhibitor of Wnt/β-catenin signaling that act downstream of the symb-catenin destruction complex to inhibit both Wnt-induced and cancer associated constitutive Wnt signaling via destabilization of β-catenin. The compound chelates iron in vitro and in intact cells. M-110 inhibits the proliferation of prostate cancer cell lines with IC₅₀s of 0.6 to 0.9 µM, with no activity on normal human peripheral blood mononuclear cells up to 40 µM.

Packaging

5, 25 mg in glass bottle