Méthylstat, > = 98 %(HPLC)

Name: Méthylstat, > = 98 %(HPLC)
Brand: SIGMA-ALDRICH
SKU: SML0343-25MG
Price: 924.93 USD

Code: SML0343-25MG D2-231

Non disponible en dehors du Royaume-Uni et de l'Irlande

Biochem/physiol Actions

Methylstat is an inhibitor of the Jumonji C domain-containing histone trimethyl demethylases (JHDMs). Methylstat inhibits the activity of JMJD2C (IC

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$924.93 25MG

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DOCUMENTS
ATTRIBUTS

Non disponible en dehors du Royaume-Uni et de l'Irlande

Biochem/physiol Actions

Methylstat is an inhibitor of the Jumonji C domain-containing histone trimethyl demethylases (JHDMs). Methylstat inhibits the activity of JMJD2C (IC₅₀ = 4.3 µM), with similar potency against JMJD2E and JMJD3. The compound has poor activity against dimethyl demethylases, and does not inhibit class I or II HDACs. Methylsat blocks proliferation of the esophageal carcinoma cell line KYSE150 with an IC₅₀ value of 5.1 µM.

Packaging

5, 25 mg in glass bottle

assay	≥98% (HPLC)
color	white to beige
form	powder
InChI key	MUJOCHRZXRZONW-FOCLMDBBSA-N
InChI	1S/C28H31N3O6/c1-36-27(33)16-15-26(32)31(35)18-5-4-17-29-19-21-11-13-22(14-12-21)20-37-28(34)30-25-10-6-8-23-7-2-3-9-24(23)25/h2-3,6-16,29,35H,4-5,17-20H2,1H3,(H,30,34)/b16-15+
Quality Level	100
SMILES string	O=C(NC1=CC=CC2=C1C=CC=C2)OCC3=CC=C(CNCCCCN(O)C(/C=C/C(OC)=O)=O)C=C3
solubility	DMSO: >5 mg/mL
storage temp.	2-8°C

Safety Data Sheet for SML0343-25MG
Certificat d'analyse Sigma

Cas Number

1310877-95-2

Ce produit répond aux critères suivants pour être admissible aux récompenses suivantes :

Méthylstat, > = 98 %(HPLC)

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