Merbarone, >= 98%( HPLC ), solide

Name: Merbarone, >= 98%( HPLC ), solide
Brand: SIGMA-ALDRICH
SKU: M2070-25MG
Price: 172.49 USD

Code: M2070-25MG D2-231

Non disponible en dehors du Royaume-Uni et de l'Irlande

Application

Merbarone has been used to study its effect on the occurrence of DNA lesions.

Biochem/physiol Actions

Thiobarbituric acid with anilin...

Votre prix

$172.49 25MG

Abandonné

PRÉSENTATION
SPÉCIFICATIONS
DOCUMENTS
ATTRIBUTS

Non disponible en dehors du Royaume-Uni et de l'Irlande

Application

Merbarone has been used to study its effect on the occurrence of DNA lesions.

Biochem/physiol Actions

Thiobarbituric acid with aniline joined by an amide linkage forms merbarone. It is known to prolong cell cycle progression by inducing DNA double strand breaks, retarding S phase and arresting G2 phase. This delays cell entry into mitosis. Merbarone possesses cytotoxic and genotoxic action and promotes endoreduplication. Merbarone has mild antitumor action and is also found to nephrotoxic.

Selective topoisomerase II inhibitor. Blocks topo II-mediated DNA cleavage without stabilizing DNA-topo II-cleavable complexes. Induces apoptosis in CEM cells via caspase 3 dependent mechanism.

Packaging

25 mg in glass bottle

assay	≥98% (HPLC)
drug control	regulated under CDSA - not available from Sigma-Aldrich Canada
form	solid
InChI key	JARCFMKMOFFIGZ-UHFFFAOYSA-N
InChI	1S/C11H9N3O3S/c15-8(12-6-4-2-1-3-5-6)7-9(16)13-11(18)14-10(7)17/h1-5,7H,(H,12,15)(H2,13,14,16,17,18)
SMILES string	O=C1NC(=S)NC(=O)C1C(=O)Nc2ccccc2
solubility	DMSO: >5 mg/mL
storage temp.	2-8°C

Safety Data Sheet for M2070-25MG
Certificat d'analyse Sigma

Cas Number

97534-21-9

Ce produit répond aux critères suivants pour être admissible aux récompenses suivantes :

Merbarone, >= 98%( HPLC ), solide

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