Hydrochlorure d'irinotécan, inhibiteur de topoisomerase

Non disponible en dehors du Royaume-Uni et de l'Irlande

Application

Irinotecan hydrochloride has been used:in combination with 5-fluorouracil for screening growth inhibitory functionality in MDA-MB-231 breast cancer cells.in chemosensitivity screening of high-grade appendiceal (HGA) and low-grade appendiceal (LGA) organoids.as a chemotherapeutic agent in the cytotoxicity studies in combination with heat shock proteins inhibitors (HPSC1) in HT29 colon cancer cells.

Biochem/physiol Actions

The anticancer agent, irinotecan, is a prodrug that is converted by tissue carboxylesterase to 7-ethyl-10-hydroxycamptothecin (SN-38), a potent inhibitor of DNA topoisomerase I. Its action is terminated by glucuronidation by UDP glucuronosyl transferase.

The anticancer agent, irinotecan, is a prodrug that is converted by tissue carboxylesterase to 7-ethyl-10-hydroxycamptothecin (SN-38), a potent inhibitor of DNA topoisomerase I. Its action is terminated by glucuronidation by UDP glucuronosyl transferase 1A1 (UGT1A1). It proves useful in radiation treatment of tumors by sensitizing tissue to radiation damage.

Packaging

50, 250 mg in poly bottle