C24:1 GLUCOSYL (bêta) CERAMIDE( D18 : 1/ 2

Non disponible en dehors du Royaume-Uni et de l'Irlande

Application

C24:1 Glucosyl(β) Ceramide (d18:1/24:1(15Z)) may be used:as a standard hexosylceramide for hydrophilic interaction chromatography-based liquid chromatography mass spectroscopyto test its nuclear factor of activated T-cells (NFAT) activationin human natural killer T (NKT) cell potency assays

Biochem/physiol Actions

β-Glucosylceramides (β-GlcCer) levels are elevated inlevels in Gaucher′s disease, due to the deficiency of β-glucosidase. β-GlcCer participates in the inflammatory and acquired immune responses by binding mincle on myeloid cells and has immunostimulatory activity.

General description

β-Glucosylceramides or glucocerebrosides (GlcCers) are synthesized from the glycosphingolipids by β-GlcCer synthase. They are synthesized in Golgi and endoplasmic reticulum and localized in the cytosolic side of cell membrane. GlcCers are omnipresent.

Packaging

5 mL Amber Glass Screw Cap Vial (860549P-5mg)