C24 CERAMIDE-1-PHOSPHATE (D18:1/24:0)

Non disponible en dehors du Royaume-Uni et de l'Irlande

Application

C24 Ceramide-1-Phosphate (d18:1/24:0) or N-lignoceroyl-ceramide-1-phosphate (ammonium salt) has been used as a standard to quantify ceramide content in muscle tissue samples using high-performance liquid chromatography/tandem mass spectrometry (LC/MS2).

Biochem/physiol Actions

Ceramide 1-phosphate (C1P) is a mitogenic agent, which has antiapoptotic and prosurvival activities. It negatively regulates tumor necrosis factor-α (TNFα) production stimulated by lipopolysaccharide. C1P also mediates inflammatory response and aids in phagocytosis. It is considered as a second lipid messenger of agonist-stimulated sphingomyelin metabolism.

General description

Ceramide 1-phosphate (C1P) is a sphingolipid analog of phosphatidate.

Packaging

5 mL Amber Glass Screw Cap Vial (860527P-1mg)