N-C16-DESOXYMETHYLSPHINGANINE

Non disponible en dehors du Royaume-Uni et de l'Irlande

Biochem/physiol Actions

Dihydroceramides are also used for dihydrosphingolipids synthesis. Treatment of MCF7 cancer cells with fenretinide alters sphingolipid metabolism.

General description

N-C16-desoxymethylsphinganine is the N-acylated form of 1-desoxymethylsphinganine, a potent inhibitor of sphingolipid metabolism. Ceramide synthases (CerS) catalyzes the acylation of sphingoid bases using fatty acyl-CoA and its inhibition results in decrease of N-acylsphinganines (dihydroceramides) levels and accumulation of sphinganine. Dihydroceramides (DHCer) are intermediates of ceramide biosynthesis.

Packaging

5 mL Amber Glass Screw Cap Vial (860463P-1mg)

5 mL Amber Glass Screw Cap Vial (860463P-5mg)