VU0359595

Non disponible en dehors du Royaume-Uni et de l'Irlande

Application

VU0359595 has been used as PLD2 (phospholipase D2) inhibitor to quantitatively address functional and molecular aspects of the involvement of PLD-derived phosphatidic acid (PA) in regulated exocytosis and as PLD1 inhibitor to treat the knockout miceto study its effects on them.

Biochem/physiol Actions

VU0359595 helps to block phospholipase D (PLD) which in turn reduces deoxyribonucleoside triphosphate (dNTP) biosynthesis in glioma models.

General description

VU0359595 has been shown to selectively inhibit the PLD1 isoform at nM levels (see data below). **Images added as .gif in folder

Packaging

5 mL Amber Glass Screw Cap Vial (857371P-1mg)