3 bêta 7 bêta-DIHYDROXY - 5-CHOLESTENOCI

Non disponible en dehors du Royaume-Uni et de l'Irlande

Application

3β,7β-dihydroxy-5-cholestenoic acid may be used as an authentic diastereoisomer standard in mass spectrometry (MS) experiments.

Biochem/physiol Actions

3β,7β-dihydroxy-5-cholestenoic acid (3β,7β-diHCA) levels are elevated in Niemann-Pick type C (NPC) disease and Niemann-Pick (NP) disease type B disorders. It elicits toxicity to oculomotor neurons.

General description

3β,7β-dihydroxy-5-cholestenoic acid (3β,7β-diHCA) is associated with plasma and is a C27 acid. 3β,7β-diHCA is synthesized from 3β-hydroxy-7-oxocholest-5-en-(25R)26-oic acid (3βH,7O-CA) by the action of the enzyme hydroxysteroid 11-β dehydrogenase 1.

Packaging

5 mL Amber Glass Screw Cap Vial (700029P-1mg)