Zebularine

Non disponible en dehors du Royaume-Uni et de l'Irlande

Biochem/physiol Actions

Reversible: no

Product does not compete with ATP.

Primary TargetCytidine deaminase

Cell permeable: yes

General description

A chemically stable, cytidine analog that displays anti-tumor properties. Acts as a transition state analog inhibitor of cytidine deaminase by binding to the active size as covalent hydrates. Also shown to inhibit DNA methylation and tumor growth both in vitro and in vivo.

A cell-permeable chemically stable cytidine analog that displays antitumor properties. Acts as transition state analog inhibitor of cytidine deaminase by binding at the active site as covalent hydrates. Also shown to inhibit DNA methylation and tumor growth both in vitro and in vivo.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Cheng, J.C., et al. 2004. Cancer Cell6, 151.Cheng, J.C., et al. 2003. J. Natl. Cancer Inst.95, 399.Zhou, L., et al. 2002. J. Mol. Biol.321, 591.Barchi, J.J., Jr., et al. 1992. J. Org. Chem.57, 536.Frick, L., et al. 1989. Biochemistry28, 9423.

Packaging

Packaged under inert gas

10, 25 mg in Plastic ampoule

Preparation Note

Slight warming may be required to achieve complete solubilization.

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.r>r>r>From Catalog:r>Desc. Field- added "cell-permeable"

Warning

Toxicity: Standard Handling (A)