Non disponible en dehors du Royaume-Uni et de l'Irlande
General description
A cell-permeable benzothiophene compound that modulates the coupling of Smo with its downstream effector by interacting with the Smo heptahelical domain (KD = 59 nM). Shown to induce Hedgehog pathway activation (EC50 ~3 nM in NIH 3T3-derived Shh-LIGHT2 cells) and counteracts Cyclopamine-KAAD (Cat. No. 239804) inhibition of Smo. Reported to act as an activator at low concentrations and as an inhibitor at very high concentrations.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Other Notes
Meloni, A.R., et al. 2006. Mol. Cell. Biol.26, 7750.Chen, W., et al. 2004. Science306, 2257.Chen, J.K., et al. 2002. Proc. Natl. Acad. Sci. USA99, 14071.Frank-Kamenetsky, M., et al. 2002. J. Biol.1, 10.
Packaging
Packaged under inert gas
500 µg in Plastic ampoule
Physical form
A 10 mM (500 µg/86 µl) solution of Smoothened Agonist, SAG (Cat. No. 566660) in H2O.
Reconstitution
Following initial thaw, aliquot and freeze (-20°C).
Warning
Toxicity: Standard Handling (A)
Ce produit répond aux critères suivants pour être admissible aux récompenses suivantes :