Non disponible en dehors du Royaume-Uni et de l'Irlande
Biochem/physiol Actions
Reversible: yes
Product does not compete with ATP.
Primary TargetP-Glycoprotein
Cell permeable: yes
General description
A cell-permeable cinnamoyl compound that reversibly inhibits P-gp (P-glycoprotein) efflux function and reverses the MDR (multidrug resistance) phenotype with no noticeable effect on P-gp expression. Shown to significantly enhance Paclitaxel- (Cat. No. 580555) and Vincristine- (Cat. No. 677181) induced cytotoxicity as well as apoptosis in P-gp expressing KBV20C cells.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Other Notes
Kim, Y.K., et al. 2007. Biochem. Biophys. Res. Commun.355, 136.Woo, H.B., et al. 2005. Bioorg. Med. Chem. Lett.15, 3782.
Packaging
Packaged under inert gas
10 mg in Plastic ampoule
Warning
Toxicity: Standard Handling (A)
Ce produit répond aux critères suivants pour être admissible aux récompenses suivantes :