Non disponible en dehors du Royaume-Uni et de l'Irlande
Biochem/physiol Actions
Primary TargetnAChR
Target Ki: 2, 5890, 480, 329, and 492 nM at &alpha
Reversible: yes
General description
A potent agonist selective for neuronal nAChRs (Ki = 2, 5890, 480, 329, and 492 nM at α4β2, α7, α3β4, α6/α4β4, α1β1γδ, respectively). Clinically used as a smoking cessation medicine and often used in addiction studies.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Other Notes
Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Chen, Y., et al., 2012. Br J Pharmacol.165, 1006.West, R., 2011, N. Engl. J. Med.365, 1193.r>Happe, K., et al., 1994. Neurosci.62, 929.r>Reavill, C. et al., 1990. Neuropharmacol.29, 619.
Reconstitution
Following reconstitution, aliquot and freeze (-20°C. Stock solutions are stable for up to 3 months at -20°C.
Warning
Toxicity: Toxic (F)
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