(5Z )-7 - Oxozeaenol;Curvularia sp.

Non disponible en dehors du Royaume-Uni et de l'Irlande

General description

A naturally isolated cell-permeable fungal resorcylic lactone that acts as a selective and highly potent inhibitor against the MAPKKK TAK1 activity (IC₅₀ = 8 nM) in an ATP-competitive and irreversible manner, while inhibiting MEK1 (IC₅₀ = 411 nM) and three other MAPKKKs (IC₅₀ ≥268 nM against MEKK1, ASK1, and MEKK4) only at much higher concentrations. Shown to inhibit IL-1-induced/TAK1-mediated, but not H₂O₂-induced/TAK1-independent, JNK and p38 phosphorylation in 293 cells. (5Z)-Zeaenol, Curvularia sp.(Cat. No. 499609) may serve as a negative control.

A naturally isolated cell-permeable fungal resorcylic lactone that acts as a selective and highly potent inhibitor against the MAPKKK TAK1 activity (IC₅₀ = 8 nM) in an ATP-competitive and irreversible manner, while inhibiting MEK1 (IC₅₀ = 411 nM) and three other MAPKKKs (IC₅₀ ≥268 nM against MEKK1, ASK1, and MEKK4) only at much higher concentrations. Shown to inhibit IL-1-induced/TAK1-mediated, but not H₂O₂-induced/TAK1-independent, JNK and p38 phosphorylation in 293 cells. (5Z)-Zeaenol, Curvularia sp. (Cat. No. 499609) may serve as a negative control.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Windheim, M., et al. 2007. Biochem. J.404, 179.Choo, M.K., et al. 2006. Mol. Cancer Ther.5, 2970.Safwat, N., et al. 2005. Endocrinology146, 4814.Ninomiya-Tsuji, J., et al. 2003. J. Biol. Chem.278, 18485.Rawlins, P., et al. 1999. Int. J. Immunopharmacol.21, 799.

Packaging

1 mg in Glass bottle

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Warning

Toxicity: Standard Handling (A)